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Computation of Total Kidney Volume from CT Images in Autosomal Dominant Polycystic Kidney Disease Using Multi-task 3D Convolutional Neural Networks

2024.03.05Publications

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease that causes numerous cysts (fluid-filled sacs) to develop in kidneys (Figure 1). With recent advances  in medicines, drugs exist which can slow the rate of cysts growth. It is recommended that these drugs be used after evaluation of the patient’s age and stage of disease, as well as whether the disease is progressing rapidly. Rapid progression means total kidney volume (TKV) increases of over 5% per year. In other words, TKV should be measured within 5% precision to be useful in clinical practice. In this paper [1], authors propose multi-task 3D Convolutional Neural Networks to segment ADPK and simply bootstrap cross entropy loss. Experiments show that mean absolute percentage TKV error achieve 3.86% (Figure 2, 3). In the future, it is hoped that ADPK can be segmented with greater accuracy, which will help in the management and treatment of ADPK.

Figure 1. Comparison of normal kidney and autosomal dominant polycystic kidney (ADPK). [based on [1]]
Figure 2. Qualitative comparison of results. [1]

Figure 3. Scattered plot showing percentage TKV error over the entire dataset. [1]
[1] Keshwani, D., Kitamura, Y., Li, Y. (2018). Computation of Total Kidney Volume from CT Images in Autosomal Dominant Polycystic Kidney Disease Using Multi-task 3D Convolutional Neural Networks. In: Shi, Y., Suk, HI., Liu, M. (eds) Machine Learning in Medical Imaging. MLMI 2018. Lecture Notes in Computer Science(), vol 11046. Springer, Cham.

DOI: https://doi.org/10.1007/978-3-030-00919-9_44


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