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Applicability of artificial intelligence-based computer-aided detection (AI-CAD) for pulmonary tuberculosis to community-based active case finding

2024.09.09Publications

Tuberculosis (TB) is a health-threatening infectious disease caused by a bacterium, with an estimated 10.6 million incident cases and 1.6 million deaths. While the World Health Organization (WHO) recommends Xpert testing which is rapid diagnosis of pleural TB using sputum, more attention has been given to the role of chest radiography (CXR) for the diagnosis or screening because there are persons without typical TB symptoms. In this paper [1], the authors develop a new AI which predicts a classification score and a localization map of TB using a CNN (convolutional neural network) model. Performance evaluation shows that its AUROC as the bacteriological reference was 0.86 (95% confidence interval 0.83–0.89). In addition, detecting 95% of Xpert-positive TB in ACF using a threshold for triage purposes and 98% of Xpert-positive TB cases for screening purposes, respectively. In the future, it is hoped that such AI will help early detection and early treatment of TB even in areas with a shortage of expert doctors.

Figure 1. Interquartile ranges of TB scores by classification of human readings for chest X-ray. [1]

Figure 2. Performance of AI and human reading. [1]
[1] Okada, K., Yamada, N., Takayanagi, K. et al. Applicability of artificial intelligence-based computer-aided detection (AI–CAD) for pulmonary tuberculosis to community-based active case finding. Trop Med Health 52, 2 (2024).

DOI: https://doi.org/10.1186/s41182-023-00560-6


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