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Deep Learning-based Hierarchical Brain Segmentation with Preliminary Analysis of the Repeatability and Reproducibility

2025.01.06Publications

Brain volume changes with development and senescence. Especially, abnormal changes in the brain volume may be associated with brain disorders, such as Alzheimers disease. In this paper [1], the authors developed a deep learning model to segment 107 brain subregions in T1-weighted MR images (T1WI) (Figure 1). To evaluate reproducibility and repeatability, 3D-T1WI scan–rescan data of the 11 healthy subjects using three MRI scanners were obtained. As results, the proposed method showed the best performance in both repeatability and reproducibility compared with representative brain segmentation tools (Figure 2). In the future, it is expected that the evaluation of brain volume using MRI will become easier, and that it will help to the diagnosis of brain disorders. 

Figure 1. Processing pipeline of the proposed method. [1]

Figure 2. Examples volumetry results. [1]
Blue regions are segmentation areas by FreeSurfer which is a representative brain segmentation tool and red regions were segmentation areas by the proposed method.
[1] Goto, Masami, et al. “Deep Learning-based Hierarchical Brain Segmentation with Preliminary Analysis of the Repeatability and Reproducibility.” Magnetic Resonance in Medical Sciences (2024): mp-2023. 

DOI: https://doi.org/10.1002/jhbp.1357


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